Carbenicillin disodium

SKU: orb1224987

Description

Carbenicillin inhibits the cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidase on the inner surface of the bacterial cell membrane. Carbenicillin is a white to slightly yellow, hygroscopic powder soluble in water and in alcohol. Carbenicillin is most effective against gram-negative bacteria but may also have some effect against gram-positive bacteria. (In Vivo):Carbenicillin (100-400 mg/kg; intramuscular injection every 8 h for 72 h) disodium significantly reduces mortality of neutropenic Pseudomonas-infected rats.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 4800-94-6
• MW: 422.36
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₆N₂Na₂O₆S
• SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)C(C3=CC=CC=C3)C(=O)[O-])C(=O)[O-])C.[Na+].[Na+]
• Target: Cell wall
• Solubility: Water: 84 mg/mL (198.88 mM); DMSO: 5 mg/mL (11.83 mM)

Bioactivity

• In Vivo:
  Carbenicillin (100-400 mg/kg; intramuscular injection every 8 h for 72 h) disodium significantly reduces mortality of neutropenic Pseudomonas-infected rats.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Cell wall