Carbazochrome sodium sulfonate

SKU: orb1310234

Description

Carbazochrome sodium sulfonate (AC-17) is a hemostatic agent used in research to investigate bleeding disorders. Its applications include studies on hemorrhoid pathophysiology and the evaluation of hemostatic mechanisms in both in vitro and animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 51460-26-5
• MW: 322.03
• Purity: 99.80% (May vary between batches)
• Formula: C₁₀H₁₁N₄NaO₅S
• SMILES: [Na+].CN1C(CC2=C\C(=N\NC(N)=O)C(=O)C=C12)S([O-])(=O)=O
• Target: Adrenergic Receptor
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:12 mg/mL (37.26 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.21 mM);H2O:3 mg/mL (9.32 mM)

Bioactivity

• In Vivo:
  Carbazochrome at concentrations of 0.1-1 M attenuates concentration-dependent synthesis of [(3)H]myo-inositol and [(3)H]-inositol induced by bradykinin and thrombin. It also counteracts the functional impairment caused by trypsin, thrombin, and bradykinin, with ionophores like ionomycin, A23187, or phorbol 12-myristate 13-acetate enhancing this effect without affecting endothelial permeability. In human umbilical vein endothelial cells, carbazochrome significantly reduces the ratio of t-PA antigen in the culture medium without notably affecting the PAI-1 antigen ratio. It reverses trypsin-induced actin stress fiber formation and disrupts VE-cadherin in monolayers of porcine aortic endothelial cells. Additionally, in cultured bovine vascular endothelial cells, carbazochrome distinctly inhibits hyperpermeability induced by trypsin, thrombin, and protease-activated receptor 2 agonist peptides.
• In Vitro:
  Administering 10 mg/kg of Carbazochrome significantly inhibited the reduction of arterial oxygen levels. Additionally, at the same dosage, Carbazochrome reversed the iodocetate-induced increase in vascular permeability in rats in a dose-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

stabiliser, inhibit, Inhibitor, haemorrhage, AdrenergicReceptor, Adrenergic Receptor, AC 17, AC17, AC-17, antihemorrhagic, capillary, Carbazochrome sodium sulfonate

Compound Identifiers

PubChem CID

135705561