Carbazochrome sodium sulfonate

SKU: orb1224855

Description

Carbazochrome sodium sulfonate (AC-17) is an antihemorrhagic for use in the treatment of hemorrhoids(In Vitro):Carbazochrome (0.1-10 μM) inhibits the Bradykinin induced and thrombin-induced formation of [3H]IP3 in a concentration-dependent manner. Carbazochrome (0.1-1 μM), when included from 30 min before stimulation, significantly suppressed the enhancement of permeability induced by vasoactive substances.(In Vivo):Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i.v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats.

Key Properties

• CAS Number: 51460-26-5
• MW: 376.32
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₇N₄NaO₈S
• SMILES: O=C(/C(C(/C=C/C1=CC=C(OC)C(OC)=C1)=O)=C/C2=CC=C(O)C(OC)=C2)/C=C/C3=CC=C(OC)C(OC)=C3
• Target: Others
• Solubility: Water: 3 mg/mL (9.3 mM); DMSO: 64 mg/mL (198.59 mM)

Bioactivity

• In Vivo:
  Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i. v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Animal model: Male Sprague-Dawley rats weighing 180-230 g. Dosage: 1, 5 and 10 mg/kg. Administration: I. v. ; injected 30, 60, or 90 min before Ioxaglate injection (4 g I/kg, i. v.). Result: Attenuated the Ioxaglate-increased vascular permeability at the dose of 1, 5 and 10 mg/kg in a dose-dependent manner, achieving statistical significance at 5 and 10 mg/kg.
• In Vitro:
  Carbazochrome (0.1-10 μM) inhibits the Bradykinin induced and thrombin-induced formation of [3H]IP3in a concentration-dependent manner. Carbazochrome (0.1-1 μM), when included from 30 min before stimulation, significantly suppressed the enhancement of permeability induced by vasoactive substances.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AC17 | 4arylidene curcumin |

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