Capsiate

SKU: orb1684070

Description

Capsiate is a non-pungent, orally bioavailable capsaicin analog that acts as a TRPV1 agonist. It exhibits antiallergic, anti-inflammatory, and antioxidant properties, with research applications in studying metabolic disorders and angiogenesis in both in vitro and in vivo models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 205687-01-0
• MW: 306.4
• Purity: 99.24% (May vary between batches)
• Formula: C₁₈H₂₆O₄
• SMILES: C(OC(CCCC/C=C/C(C)C)=O)C1=CC(OC)=C(O)C=C1
• Target: TRP/TRPV Channel,Antioxidant
• Solubility: DMSO:90 mg/mL (293.73 mM)

Bioactivity

• Target IC50:
  TRPV1:290 nM(EC50)
• In Vivo:
  Capsiate (0.03~0.54 mM; s.c.) induces nociceptive responses in mice. Topical application of Capsiate reduces antigen-induced increases in ear thickness in a mouse model of passive cutaneous anaphylaxis and decreases epidermal thickness and eosinophil and mast cell infiltration in a mouse model of atopic dermatitis. Capsiate (10 mg/kg) decreases body weight gain and perirenal fat weight, as well as increases oxygen consumption, fat oxidation, and carbohydrate oxidation, in a mouse model of ad libitum feeding-induced weight gain.
• In Vitro:
  Capsiate elicits current responses in HEK293 cells expressing TRPV1. Additionally, Capsiate (5 to 25 µM) inhibits Src and VEGF-induced proliferation and tube formation in human umbilical vein endothelial cells (HUVECs).

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antioxidant, Capsiate, TRPV1, TRPVChannel, TRPV Channel, TRPChannel, TRP Channel

Compound Identifiers

PubChem CID

9839519