Calmidazolium chloride

SKU: orb1940814

Description

Calmidazolium chloride is a calmodulin (CaMK) antagonist (Kd = 3 nM), antagonizing CaM-dependent phosphodiesterase(IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase(IC50 = 0.35 μM). Calmidazolium chloride also induces apoptosis in certain cancer cell lines.(In Vitro):Calmidazolium chloride inhibits growth of mouse F9 ECCs (IC50 = 8.18 μM) and E14 ESCs (IC50 = 12.69 μM).

Key Properties

• CAS Number: 57265-65-3
• MW: 687.69
• Purity: >98% (HPLC)
• Formula: C₃₁H₂₃Cl₇N₂O
• SMILES: [Cl-].Clc1ccc(cc1)C(c1ccc(Cl)cc1)[n+]1ccn(CC(OCc2ccc(Cl)cc2Cl)c2ccc(Cl)cc2Cl)c1
• Target: CaMK
• Solubility: In Vitro: DMSO : 100 mg/mL (145.41 mM)

Bioactivity

• In Vitro:
  Calmidazolium chloride is widely used as a calmodulin (CaM) antagonist, but is also known to induce apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits growth of mouse F9 ECCs. Cell Viability Assay Cell line: Mouse F9 ECCs. Concentration: 3, 5, 7, 10 μM. Incubation time: 30 minutes-24 hours. Result: The IC50s of Calmidazolium chloride treated F9 ECCs and E14 ESCs are 8.18 μM, and 12.69 μM.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

R 24571

Quick Database Links

Gene Symbol

CaMK