Calmidazolium chloride

SKU: orb1309880

Description

Calmidazolium chloride (R 24571) is a potent calmodulin antagonist with a Kd of 3 nM, inhibiting CaM-dependent enzymes like phosphodiesterase and Ca2+-ATPase. It is widely used in biochemical research to study calcium signaling pathways and has been shown to induce apoptosis in various cancer cell lines in vitro.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 57265-65-3
• MW: 687.7
• Purity: 98.53% (May vary between batches)
• Formula: C₃₁H₂₃Cl₇N₂O
• SMILES: [Cl-].Clc1ccc(cc1)C(c1ccc(Cl)cc1)[n+]1ccn(CC(OCc2ccc(Cl)cc2Cl)c2ccc(Cl)cc2Cl)c1
• Target: CaMK,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (4.8 mM);DMSO:240 mg/mL (348.99 mM)

Bioactivity

• Target IC50:
  PDE (CaM-dependent):0.15 μM|Calmodulin:12.69 μM(mouse E14 ESCs)|Calmodulin:3 nM(kd)|Calmodulin:8.18 μM(mouse F9 ECCs)|Ca2+ transporting ATPase (erythrocyte, Calmodulin-induced):0.35 μM
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• In Vitro:
  Calmidazolium chloride also induces apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits the growth of mouse F9 ECCs .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

R 24571, R24571, R-24571, Inhibitor, inhibit, Calmodulin-dependent protein kinases, Calmodulin-dependent kinases, Calmodulin, calmodulin, Calmidazolium, Calmidazolium chloride, Calmidazolium Chloride, CaMK, Autophagy

Compound Identifiers

PubChem CID

644274