Caffeic Acid Phenethyl Ester

SKU: orb1222903

Description

Caffeic Acid Phenethyl Ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective and immunomodulating activities. CAPE is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1).

Key Properties

• CAS Number: 104594-70-9
• MW: 284.31
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₆O₄
• SMILES: c1ccc(cc1)CCOC(=O)/C=C/c1ccc(c(c1)O)O
• Target: NF-κB
• Solubility: DMSO : 150 mg/mL. 527.59 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CAPE | Caffeic Acid Phenethyl Ester | β-Phenylethyl Caffeate

Quick Database Links

Gene Symbol

NF-κB