CA8 Antibody / Carbonic Anhydrase VIII

SKU: orb1822883

Description

The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 gene causes neuropathology, such as ataxia, mild mental retardation and the predisposition to quadrupedal gait. It is also associated with the development of colorectal and lung cancers. Additionally, it is upregulated in various cancers.

Images & Validation

• Tested Applications: WB
• Dilution range: Western blot: 2-4ug/ml
• Reactivity: Human

Key Properties

• Antibody Type: Primary Antibody
• Host: Mouse
• Clonality: Recombinant
• Isotype: Mouse IgG1, kappa
• Clone No.: rCA8/8835
• Immunogen: Recombinant full-length human protein was used as the immunogen for the CA8 antibody.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Disclaimer: For research use only

Western blot testing of human K562 cell lysate with CA8 antibody.

Western blot testing of human K562 cell lysate with CA8 antibody.

SDS-PAGE analysis of purified, BSA-free CA8 antibody (clone rCA8/8835) as confirmation of integrity and purity.

Quick Database Links

UniProt

P35219