CA8 Antibody / Carbonic Anhydrase VIII

Catalog Number: orb1822883

Catalog Number	orb1822883
Category	Antibodies
Description	The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 gene causes neuropathology, such as ataxia, mild mental retardation and the predisposition to quadrupedal gait. It is also associated with the development of colorectal and lung cancers. Additionally, it is upregulated in various cancers.
Clonality	Recombinant
Species/Host	Mouse
Isotype	Mouse IgG1, kappa
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant full-length human protein was used as the immunogen for the CA8 antibody.
UniProt ID	P35219
Tested applications	WB
Dilution range	Western blot: 2-4ug/ml
Antibody Type	Primary Antibody
Clone Number	rCA8/8835
Formula	1 mg/ml in 1X PBS; BSA free, sodium azide free
Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Note	For research use only
Expiration Date	12 months from date of receipt.

Western blot testing of human K562 cell lysate with CA8 antibody.

SDS-PAGE analysis of purified, BSA-free CA8 antibody (clone rCA8/8835) as confirmation of integrity and purity.