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Ca2+ channel agonist 1

SKU: orb1940815

Description

Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction.(In Vitro):Ca2+ channel agonist 1 (Compound 13d) exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.

Images & Validation

Key Properties

CAS Number1402821-24-2
MW354.458
Purity>98% (HPLC)
FormulaC19H26N6O
SMILESCCCn1cnc2c(NCc3ccccc3)nc(N[C@H](CC)CO)nc12
TargetCalcium Channel
SolubilityIn Vitro: DMSO : 50 mg/mL (141.06 mM)

Bioactivity

In Vitro
Ca2+ channel agonist 1 (Compound 13d) is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively. Ca2+ channel agonist 1 exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Ca2+ channel agonist 1 (orb1940815)

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% DMSO +
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% Tween 80 +
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5 mg
$ 480.00
10 mg
$ 670.00
25 mg
$ 1,040.00
50 mg
$ 1,470.00
100 mg
$ 1,970.00
500 mg
$ 3,810.00