Ca2+ channel agonist 1

SKU: orb1309883

Description

This small molecule acts as an N-type calcium channel agonist and a Cdk2 inhibitor, with EC50 values of 14.23 µM and 3.34 µM, respectively. It is a research tool for studying motor nerve terminal dysfunction and has been utilized in both cellular and animal models of neurological disorders.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1402821-24-2
MW	354.45
Purity	97.71% (May vary between batches)
Formula	C₁₉H₂₆N₆O
SMILES	CCCn1cnc2c(NCc3ccccc3)nc(N[C@H](CC)CO)nc12
Target	CDK,Calcium Channel
Solubility	DMSO:45 mg/mL (126.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.64 mM)

Bioactivity

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Target IC50	CDK2:3.34 μM (EC50)\|Ca2+ channel, N-type:14.23 μM (EC50)
In Vitro	Ca2+ channel agonist 1 (Compound 13d) exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CDK, CDK2, Cyclin dependent kinase, Ca channels, Ca2+ channel agonist 1, Ca-2+ channel agonist 1, Ca2+ channels, Calcium Channel, CalciumChannel, Inhibitor, N-Type Ca2+ Channel, inhibit

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Compound Identifiers

PubChem CID

69472592 ↗

Key Properties

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No computed properties available.

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