Ca2+ channel agonist 1

SKU: orb1309883

Description

This small molecule acts as an N-type calcium channel agonist and a Cdk2 inhibitor, with EC50 values of 14.23 µM and 3.34 µM, respectively. It is a research tool for studying motor nerve terminal dysfunction and has been utilized in both cellular and animal models of neurological disorders.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1402821-24-2
• MW: 354.45
• Purity: 98.21% (May vary between batches)
• Formula: C₁₉H₂₆N₆O
• SMILES: CCCn1cnc2c(NCc3ccccc3)nc(N[C@H](CC)CO)nc12
• Target: CDK,Calcium Channel
• Solubility: DMSO:45 mg/mL (126.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.64 mM)

Bioactivity

• Target IC50:
  CDK2:3.34 μM (EC50)|Ca2+ channel, N-type:14.23 μM (EC50)
• In Vitro:
  Ca2+ channel agonist 1 (Compound 13d) exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDK, CDK2, Cyclin dependent kinase, Ca channels, Ca2+ channel agonist 1, Ca-2+ channel agonist 1, Ca2+ channels, Calcium Channel, CalciumChannel, Inhibitor, N-Type Ca2+ Channel, inhibit

Compound Identifiers

PubChem CID

69472592