C75

SKU: orb1710175

Description

C75 is a synthetic fatty acid synthase (FASN) inhibitor with an IC50 of 35 µM against prostate cancer PC3 cells. It promotes CPT1 activity and has been shown to reduce diet-induced obesity (DIO) in research models, making it a useful tool for studying cancer metabolism and metabolic disorders in vitro and in vivo.

Research Area

Metabolism Research

Key Properties

• CAS Number: 218137-86-1
• MW: 254.32
• Purity: >99.99% (May vary between batches)
• Formula: C₁₄H₂₂O₄
• SMILES: CCCCCCCCC1OC(=O)C(=C)C1C(O)=O
• Target: Fatty Acid Synthase
• Solubility: 0.5% CMC-Na:5 mg/mL (19.66 mM);DMSO:75.6 mg/mL (297.26 mM)

Bioactivity

• Target IC50:
  OVCAR-3 cells:21.9 μM|MCF-7 cells:27.3 μM|SKBR3 cells:19.8 μM|Fibroblast:63.2 μM|HCT116 cells:46.4 μM|PC3 cells:35 μM|LNCaP cells:50 μM|MIAPaCa2 cells:21.8 μM|MDA-MB-231 cells:43.8 μM
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• In Vivo:
  C75 (i.p.) blocks fasting-induced c-Fos expression in the arcuate nucleus, lateral hypothalamic area, and paraventricular nucleus. C75 (30 mg/kg, i.p.) inhibits the food intake of mice by ≥95% within 2 h. C75-treated DIO mice have a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA .
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• In Vitro:
  C75 (10-50 μM) reduces the growth of LNCaP spheroids in a concentration-dependent manner (IC50: 50 μM). (-)-C75 inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption. (+)-C75 inhibits CPT1 and produces anorexia. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PC3 cell, FattyAcidSynthase, Fatty Acid Synthase (FASN), Fatty Acid Synthase, C 75, C75, C-75

Compound Identifiers

PubChem CID

4248455