trans-C75

SKU: orb1309884

Description

trans-C75, the (±)-enantiomer of C75, is a well-characterized inhibitor of fatty acid synthase (FASN). This small molecule is widely used in metabolic and cancer research to study lipid metabolism and tumor growth inhibition in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 191282-48-1
• MW: 254.32
• Purity: 98.79% (May vary between batches)
• Formula: C₁₄H₂₂O₄
• SMILES: CCCCCCCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O
• Target: Fatty Acid Synthase
• Solubility: DMSO:83.3 mg/mL (327.54 mM)

Bioactivity

• Target IC50:
  PC3 cells:35 μM (IC50)
• In Vitro:
  Treatment with C75 alone decreased clonogenic survival, an effect that was abrogated by the antioxidant. C75 treatment also delayed spheroid growth in a concentration-dependent manner. The radiosensitizing effect of C75 was indicated by combination index values between 0.65 and 0.71 and the reduced surviving fraction of clonogens, in response to 2 Gy X irradiation, from 0.51 to 0.30 and 0.11 in the presence of 25 and 35 μM C75, respectively. This increased sensitivity to radiation was reduced by the presence of the antioxidant. The C75 treatment also enhanced the spheroid growth delay induced by X irradiation in a supra-additive manner. The level of radiation-induced apoptosis in prostate cancer cells was increased further by C75, which induced cell cycle arrest in the G2/M phase, but only at a concentration greater than that required for radiosensitization.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(±)-C75, C75, C-75, C 75, inhibit, PC3 cell, Fatty Acid Synthase, Fatty Acid Synthase (FASN), FattyAcidSynthase, FAS, Inhibitor, transC75, trans-C75, trans-C-75, trans C75

Compound Identifiers

PubChem CID

9881506