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C3d / Complement 3d Antibody

C3d / Complement 3d Antibody

Catalog Number: orb639977

DispatchUsually dispatched within 5-10 working days
$ 764.00
Catalog Numberorb639977
CategoryAntibodies
DescriptionThe complement component proteins, C2, C3, C4 and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3d is a terminal degradation product of C3 that plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2). CR2 is important in the switched-isotype, high-affinity and memory humoral immune responses to T-dependent foreign antigens, as well as in the development of the natural antibody repertoire. This pH- and ionic strength-dependent association of C3d with CR2 represents a link between innate and adaptive immunity.
Species/HostMouse
ClonalityMonoclonal
Clone NumberC3D/2891
Tested applicationsIHC-P
ReactivityHuman
IsotypeMouse IgG2b, kappa
ImmunogenA portion of amino acids 1250-1450 from human Complement C3 protein was used as the immunogen for this Complement 3d antibody.
Dilution rangeImmunohistochemistry (FFPE): 1-2ug/ml
PurityProtein G affinity chromatography
ConjugationUnconjugated
Formula0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Hazard InformationThis Complement 3d antibody is available for research use only.
UniProt IDP01024
StorageStore the Complement 3d antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Buffer/Preservatives0.2 mg/ml with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide
NoteFor research use only
Application notesOptimal dilution of the antibody should be determined by the researcher.
Expiration Date12 months from date of receipt.
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