c-Kit-IN-1

SKU: orb1223383

Description

DCC-2618 is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).(In Vitro):c-Kit-IN-1 is a c-Kit and c-Met inhibitor extracted from patent 2010051373A1, compound example 45, has an IC50 of <200 nM. c-Kit-IN-1 also inhibits KDR, PDGFR α and β with IC50s of <2 μM, <10 μM and <10 μM, respectively.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1225278-16-9
• MW: 489.47
• Purity: >98% (HPLC)
• Formula: C₂₆H₂₁F₂N₅O₃
• SMILES: Cn1cc(cn1)c1nccc(c1)Oc1c(cc(c(c1)F)NC(=O)C1(CC1)C(=O)Nc1ccccc1)F
• Target: CaMK
• Solubility: DMSO : ≥ 100 mg/mL. 204.30 mM

Bioactivity

• In Vitro:
  c-Kit-IN-1 is a c-Kit and c-Met inhibitor extracted from patent 2010051373A1, compound example 45, has an IC50 of <200 nM. c-Kit-IN-1 also inhibits KDR, PDGFR α and β with IC50s of <2 μM, <10 μM and <10 μM, respectively.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CaMK