C-DIM12

SKU: orb1222598

Description

C-DIM12 is a novel synthetic activator of Nurr1. C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. C-DIM12 activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice. C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA. C-DIM12 stimulates neuroprotective expression Nurr1-regulated genes in DA neurons.

Key Properties

• CAS Number: 178946-89-9
• MW: 356.85
• Purity: >98% (HPLC)
• Formula: C₂₃H₁₇ClN₂
• SMILES: Clc1ccc(C(c2c[nH]c3c2cccc3)c2c[nH]c3c2cccc3)cc1
• Target: Nurr1 activator
• Solubility: DMSO : ≥ 100 mg/mL 280.23 mM; H2O : < 0.1 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

C-DIM12 | C-DIM 12 | C-DIM-12

Quick Database Links

Gene Symbol

Nurr1 activator