C-021

SKU: orb1306167

Description

C-021 dihydrochloride is a potent and selective CCR4 antagonist, inhibiting human and mouse chemotaxis with IC50 values of 140 nM and 39 nM, respectively. It blocks CCL22-induced GTPγS binding (IC50: 18 nM) and is a valuable tool for investigating CCR4-mediated responses in both in vitro and in vivo immunological research models.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 864289-85-0
• MW: 467.65
• Purity: >99.99% (May vary between batches)
• Formula: C₂₇H₄₁N₅O₂
• SMILES: N(C=1C2=C(N=C(N1)N3CCC(CC3)N4CCCCC4)C=C(OC)C(OC)=C2)C5CCCCCC5
• Target: CCR
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.07 mM);DMSO:9 mg/mL (19.25 mM)

Bioactivity

• Target IC50:
  CCR4:140 nM (human)|CCR4:39 nM(mice)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4-​Quinazolinamine, 2-​[1,​4'-​bipiperidin]​-​1'-​yl-​N-​cycloheptyl-​6,​7-​dimethoxy-, CCR, CCL22, C 021, C021, C-021, CC chemokine receptor, CCR4, chemotaxis, inhibit, Inhibitor, GTPγS

Compound Identifiers

PubChem CID

25141190