C-021 dihydrochloride

SKU: orb1309891

Description

C-021 dihydrochloride is a potent and selective CCR4 antagonist, effectively blocking chemotaxis in both human and mouse cells with IC50 values of 140 nM and 39 nM, respectively. This compound is a valuable research tool for studying CCR4-mediated immune responses in various in vitro and in vivo models of inflammation, allergy, and cancer.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1784252-84-1
• MW: 540.57
• Purity: 98.67% (May vary between batches)
• Formula: C₂₇H₄₃Cl₂N₅O₂
• SMILES: Cl.Cl.COc1cc2nc(nc(NC3CCCCCC3)c2cc1OC)N1CCC(CC1)N1CCCCC1
• Target: CCR
• Solubility: DMSO:5.41 mg/mL (10.01 mM);H2O:9.25 mg/mL (17.11 mM)

Bioactivity

• In Vivo:
  In the murine oxazolone-induced contact hypersensitivity test, the potency of C-021 is evident after subcutaneous administration. When C-021 is administered orally, however, very little inhibition is observed. C-021 (1 mg/kg; i.p.; daily; for 3 days) significantly less microgliosis in acute liver failuremice
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• In Vitro:
  C-021 (Compound 1b) effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor (IC50: 18 nM). In human liver microsomes (HML), C-021 exhibits CLint value of 17,377 mL/h/kg.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CCR, CCL22, C021, C-021, C021 dihydrochloride, C021 Dihydrochloride, C-021 Dihydrochloride, C 021, C 021 dihydrochloride, C 021 Dihydrochloride, CC chemokine receptor, CCR4, chemotaxis, inhibit, Inhibitor, GTPγS

Compound Identifiers

PubChem CID

56972238