Butein

SKU: orb1223116

Description

Butein is found in Rhuteic verniciflua and Butea monosperma. It induces cell cycle arrest and apoptosis in lung cancer cells, inhibits vessel spouting from aortic rings, and prevents hepatic stellate cell activation.

Key Properties

• CAS Number: 487-52-5
• MW: 272.25
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₂O₅
• SMILES: c1cc(c(cc1/C=C/C(=O)c1c(cc(cc1)O)O)O)O
• Target: EGFR
• Solubility: DMSO : ≥ 35 mg/mL128.56 mM

Bioactivity

• In Vivo:
  Animal model: Nude mice (12 female 6-or 7-week old) with subcutaneous tumor xenografts. Dosage: 2 mg/kg. Administration: Intraperitoneally; every 2 days; for 3 weeks. Result: Enhanced the antitumor effects of Cisplatin In vivo.
• In Vitro:
  Cell Viability Assay Cell line: HeLa cells. Concentration: 10, 20, and 40 μM. Incubation time: 24, 48, and 72 hours. Result: Inhibited cell growth in a dose- and time-dependent manner. Western blot analysis. Cell line: HeLa cells. Concentration: 20 μM. Incubation time: 24 hours. Result: Decreased phosphorylation of AKT, ERK and p38 co-treatment with Cisplatin (20 μM).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AC1NQY7L | AC1N-QY7L | AC1N QY7L | CCG-208298

Quick Database Links

Gene Symbol

EGFR