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Butein

SKU: orb1223116

Description

Butein is found in Rhuteic verniciflua and Butea monosperma. It induces cell cycle arrest and apoptosis in lung cancer cells, inhibits vessel spouting from aortic rings, and prevents hepatic stellate cell activation.

Images & Validation

Key Properties

CAS Number487-52-5
MW272.25
Purity>98% (HPLC)
FormulaC15H12O5
SMILESc1cc(c(cc1/C=C/C(=O)c1c(cc(cc1)O)O)O)O
TargetEGFR
SolubilityDMSO : ≥ 35 mg/mL128.56 mM

Bioactivity

In Vivo
Animal model: Nude mice (12 female 6-or 7-week old) with subcutaneous tumor xenografts. Dosage: 2 mg/kg. Administration: Intraperitoneally; every 2 days; for 3 weeks. Result: Enhanced the antitumor effects of Cisplatin In vivo.
In Vitro
Cell Viability Assay Cell line: HeLa cells. Concentration: 10, 20, and 40 μM. Incubation time: 24, 48, and 72 hours. Result: Inhibited cell growth in a dose- and time-dependent manner. Western blot analysis. Cell line: HeLa cells. Concentration: 20 μM. Incubation time: 24 hours. Result: Decreased phosphorylation of AKT, ERK and p38 co-treatment with Cisplatin (20 μM).

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AC1NQY7L | AC1N-QY7L | AC1N QY7L | CCG-208298

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Protocol Information

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200 mg
500 mg
2 mg
$ 90.00
5 mg
$ 130.00
10 mg
$ 170.00
25 mg
$ 330.00
50 mg
$ 520.00
100 mg
$ 820.00