Buspirone hydrochloride

SKU: orb1306402

Description

Buspirone hydrochloride (Buspar) is a selective serotonin 5-HT1A receptor agonist employed in the treatment of generalized anxiety disorder (GAD). It is widely used in neuroscience and pharmacology research for in vitro receptor binding assays and in vivo behavioral studies related to anxiety and serotonin signaling.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 33386-08-2
• MW: 421.96
• Purity: 99.99% (May vary between batches)
• Formula: C₂₁H₃₂ClN₅O₂
• SMILES: Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
• Target: 5-HT Receptor,Dopamine Receptor,Reactive Oxygen Species,ROS
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.74 mM);DMSO:61.88 mg/mL (146.65 mM);H2O:42.2 mg/mL (100.01 mM)

Bioactivity

• In Vitro:
  Buspirone, a clinically effective non-benzodiazepine anxiolytic drug, causes inhibition of firing of these neurons when given by intravenous (ED50 = 0.011 mg/kg, i.v.), intraperitoneal (ED50 = 0.088 mg/kg, i.p.), and intragastric (effective dose = 1.0-20.0 mg/kg, i.g.) injection. Buspirone also inhibits these cells when it is administered to the outside of recorded neurons by microiontophoresis. Buspirone is eliminated primarily by oxidative metabolism, which produces several hydroxylated metabolites, including 5-hydroxy-buspirone and 1-pyrimidinylpiperazine.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dopamine, Dopamine Receptor, DopamineReceptor, depression, 5HTReceptor, 5-hydroxytryptamine Receptor, 5HT Receptor, 5-HT, 5-HT1A receptor, 5-HT Receptor, anxiety, Buspar, Buspirone, Buspirone HCl, Buspirone hydrochloride, Buspirone Hydrochloride, Narol, inhibit, Inhibitor, Reactive Oxygen Species, Serotonin Receptor

Compound Identifiers

PubChem CID

36431