BTR-1

SKU: orb1301458

Description

BTR-1 (5-Benzylidene-3-ethyl rhodanine) is a small molecule research compound with demonstrated anti-cancer activity. It functions as a pro-apoptotic agent, inducing programmed cell death in vitro, and is utilized in cancer research to study apoptotic pathways and cell viability.

Research Area

Cell Biology

Key Properties

• CAS Number: 18331-34-5
• MW: 249.35
• Purity: 98.00% (May vary between batches)
• Formula: C₁₂H₁₁NOS₂
• SMILES: CCN1C(=S)S\C(=C/c2ccccc2)C1=O
• Target: Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.02 mM);DMSO:25 mg/mL (100.26 mM)

Bioactivity

• In Vitro:
  5-isopropylidiene derivatives of 3-dimethyl-2-thio-hydantoin (ITH-1), 3-ethyl-2-thio-2,4-oxazolidinedione (ITO-1), and 5-Benzylidene-3-ethyl rhodanine(BTR-1), and have tested their chemotherapeutic properties. All three compounds induced cytotoxicity in a time- and concentration-dependent manner on leukemic cell line, CEM. Among the compounds tested, BTR-1 was 5- to 7-fold more potent than ITH-1 and ITO-1 when compared by trypan blue and MTT assays. IC(50) value of BTR-1 was estimated to be <10μM. Both cell cycle analysis and tritiated thymidine assays revealed that BTR-1 affects DNA replication by inducing a block at S phase. BTR-1 treatment led to increased level of ROS production and DNA strand breaks suggesting activation of apoptosis for induction of cell death.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-Benzylidene-3-ethyl rhodanine, Apoptosis, BTR 1, BTR1, BTR-1, Inhibitor, inhibit

Compound Identifiers

PubChem CID

2244562