5-Benzylidene-3-ethyl rhodanine

SKU: orb1220765

Description

5-Benzylidene-3-ethyl rhodanine(BTR-1) is an active anti-cancer agent. BTR-1 activates apoptosis and induces cell death.

Key Properties

• CAS Number: 18331-34-5
• MW: 249.35
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₁NOS₂
• SMILES: CCN1C(=S)S\C(C1=O)=C/c1ccccc1
• Target: Apoptosis
• Solubility: DMSO:25 mg/mL (100.26 mM)

Bioactivity

• In Vitro:
  BTR-1 (10, 50, 100, and 250 μM, 5 days) dose-dependently causes cytotoxicity in human leukemic cells, with IC50s of 8 and 6 μM at 48 and 72 h, respectively. Cell Viability Assay Cell line: T-cell leukemic cell lines. Concentration: 10, 50, 100, and 250 μM. Incubation time: 5 days. Result: Induced cytotoxicity in human leukemic cells in a dose-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis