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Catalog Number | orb639611 |
---|---|
Category | Antibodies |
Description | B and T lymphocyte attenuator (BTLA) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T-cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are coinhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T-cell activation by propagating inhibitory signals through BTLA. The BTLAHVEM interaction is conserved between Mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation. |
Species/Host | Mouse |
Clonality | Monoclonal |
Clone Number | BTLA/1528 |
Tested applications | ELISA |
Reactivity | Human |
Isotype | Mouse IgG1, kappa |
Immunogen | Recombinant extracellular human CD272/BTLA protein was used as the immunogen for this BTLA antibody. |
Dilution range | ELISA (order BSA-free format for coating) |
Purity | Protein G affinity chromatography |
Conjugation | Unconjugated |
Formula | 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
Hazard Information | This BTLA antibody is available for research use only. |
Storage | Store the BTLA antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide). |
Buffer/Preservatives | 0.2 mg/ml with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide |
Note | For research use only |
Application notes | Optimal dilution of the antibody should be determined by the researcher. |
Expiration Date | 12 months from date of receipt. |
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