BT-13

SKU: orb1309897

Description

BT-13 is a small molecule RET agonist that functions independently of GDNF family ligands. It stimulates neurite outgrowth in sensory neurons in vitro and is used in research on neuroprotection, pain, and neurodegenerative disease models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 924537-98-4
• MW: 517.54
• Purity: 99.23%
• Formula: C₂₃H₂₇F₄N₃O₄S
• SMILES: CCN(CC)S(=O)(=O)c1ccc(OC)c(c1)N1CCN(CC1)C(=O)c1ccc(F)cc1C(F)(F)F
• Target: GDNF,c-RET
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.86 mM);DMSO:25 mg/mL (48.31 mM)

Bioactivity

• In Vivo:
  In rats with surgery-induced neuropathy, BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons.
• In Vitro:
  BT-13 stimulates phosphorylation of RET and RET-dependent intracellular signaling, but does not activate the BDNF receptor TrkB, the NGF receptor TrkA, or associated intracellular signaling in the absence of RET.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, GDNF receptor RET, inhibit, cRET, BT 13, BT13, BT-13, RET

Compound Identifiers

PubChem CID

46088379