BT-13

SKU: orb1217465

Description

BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.

Key Properties

• CAS Number: 924537-98-4
• MW: 517.54
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₇F₄N₃O₄S
• SMILES: O=S(C1=CC=C(OC)C(N2CCN(C(C3=CC=C(F)C=C3C(F)(F)F)=O)CC2)=C1)(N(CC)CC)=O
• Target: c-RET
• Solubility: DMSO: 25 mg/mL (48.31 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: Rats induced by ligation of left L5 and L6 spinal nerves. Dosage: 5-25 mg/kg, dissolved in sesame oil containing 5% DMSO. Administration: Subcutaneous injections on post-surgical day 1, 3, 5, 8, 10, and 12. Result: 20 and 25 mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

c-RET