Bromoenol lactone

SKU: orb1707511

Description

Bromoenol lactone is a selective inhibitor of iPLA2β and serine proteases. It is used in research to study nicotine-induced cancer cell proliferation, voltage-gated calcium channels, and inflammatory pain models, such as carrageenan-induced hyperalgesia in vivo.

Research Area

Metabolism Research

Key Properties

• CAS Number: 88070-98-8
• MW: 317.18
• Purity: 99.98% (May vary between batches)
• Formula: C₁₆H₁₃BrO₂
• SMILES: O=C1C(C=2C3=C(C=CC2)C=CC=C3)CC/C(=C\Br)/O1
• Target: Phospholipase
• Solubility: DMSO:40 mg/mL (126.11 mM)

Bioactivity

• Target IC50:
  PLA2:7 μM
• In Vitro:
  Bromoenol lactone inhibits exocytosis when stimulated using a Ca2+ ionophore A23187, which passively transports Ca2+ down a concentration gradient and also in permeabilised mast cells where Ca2+ entry is no longer relevant. In RBL 2H3 and bone marrow-derived mast cells (BMMCs), Ca2+ entry is critical for exocytosis. Moreover, Bromoenol lactone has only a minor effect on antigen- or thapsigargin-stimulated Ca2+ signalling, both the release from internal stores and sustained elevation due to Ca2+ influx.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bromoenol lactone, (6E)-Bromoenol lactone, PLA2

Compound Identifiers

PubChem CID

5940264