Bromelain

SKU: orb1940818

Description

Bromelain is an anti-inflammatory drug derived from pineapple stem. It acts through down-regulation of plasma kininogen, degradation of advanced glycation end-product receptors, inhibition of Prostaglandin E2 expression, and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway.(In Vivo):Bromelain (40 mg/kg; i.p.; daily; for 7 days; male SD rats) pretreatment reduces the motor dysfunction in the parkinsonian rat model of Parkinson's disease. 6-OHDA injection resulted in a marked motor impairment which is prevented by pretreatment with Bromelain prior to the lesion .

Key Properties

• CAS Number: 9001-00-7
• MW: ——
• Purity: >98% (HPLC)
• Formula: ——
• SMILES: CC1OC(OC2C(NC(C)=O)C(O)OC(CO)C2OC2OC(CO)C(OC3OC(COC4OC(CO)C(O)C(O)C4O)C(O)C(O)C3OC3OCC(O)C(O)C3O)C(O)C2NC(C)=O)C(O)C(O)C1O
• Target: Apoptosis
• Solubility: In Vitro: DMSO : 6.67 mg/mL

Bioactivity

• In Vivo:
  Animal model: Male Sprague-Dawley rats injected with 6-OHDA. Dosage: 40 mg/kg. Administration: Intraperitoneal injection; daily; for 7 days. Result: Reduced the motor dysfunction in the parkinsonian rat model of parkinson's disease (PD).
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis