Bromelain

SKU: orb1309899

Description

Bromelain, a pineapple stem-derived protease, exerts anti-inflammatory effects via multiple mechanisms including kininogen down-regulation, AGE receptor degradation, and modulation of prostaglandin E2 and angiogenic factors. It is widely used in inflammation, cancer, and wound healing research, with applications in both in vitro enzymatic assays and in vivo animal models.

Research Area

Cell Biology

Key Properties

• CAS Number: 9001-00-7
• MW: 1026.942
• Formula: C₃₉H₆₆N₂O₂₉
• SMILES: CC1OC(OC2C(NC(C)=O)C(O)OC(CO)C2OC2OC(CO)C(OC3OC(COC4OC(CO)C(O)C(O)C4O)C(O)C(O)C3OC3OCC(O)C(O)C3O)C(O)C2NC(C)=O)C(O)C(O)C1O
• Target: Apoptosis
• Solubility: DMSO:3.33 mg/mL

Bioactivity

• In Vivo:
  Bromelain (40 mg/kg; i.p.; daily; for 7 days; male SD rats) pretreatment reduces the motor dysfunction in the parkinsonian rat model of Parkinson's disease. 6-OHDA injection resulted in a marked motor impairment which is prevented by pretreatment with Bromelain prior to the lesion .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Apoptosis, Bromelain

Compound Identifiers

PubChem CID

74981710