Brimonidine Tartrate

SKU: orb1300783

Description

Brimonidine Tartrate

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 70359-46-5
• MW: 442.22
• Purity: 99.83% (May vary between batches)
• Formula: C₁₅H₁₆BrN₅O₆
• SMILES: O[C@H]([C@@H](O)C(O)=O)C(O)=O.Brc1c(NC2=NCCN2)ccc2nccnc12
• Target: Adrenergic Receptor
• Solubility: H2O:56.53 mM;DMSO:16.67 mg/mL (37.7 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.52 mM)

Bioactivity

• Target IC50:
  α2A-adrenoceptor:0.45 nM(EC50)
• In Vivo:
  Brimonidine (0.5/1 mg/kg) reduced progressive ganglion cell loss (26%/15%). At elevated intraocular pressure, the use of Brimonidine significantly protected retinal ganglion cells and prevented further cell loss. Brimonidine injection into the eyes of SD rats increased the number of brain-derived neurotrophic factor-positive retinal ganglion cells from 55% to 166%. Brimonidine prevented further ganglion cell loss after 10 days of elevated IOP.Brimonidine increased immunoreactivity for glial fibrillary acidic protein in the hypertensive retina of attenuated eyes.
  Read more...
• In Vitro:
  Brimonidine (0.5/1 mg/kg) reduced progressive ganglion cell loss (26%/15%). At elevated intraocular pressure, the use of Brimonidine significantly protected retinal ganglion cells and prevented further cell loss. Brimonidine injection into the eyes of SD rats increased the number of brain-derived neurotrophic factor-positive retinal ganglion cells from 55% to 166%. Brimonidine prevented further ganglion cell loss after 10 days of elevated IOP.Brimonidine increased immunoreactivity for glial fibrillary acidic protein in the hypertensive retina of attenuated eyes.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Brimonidine, Brimonidine Tartrate, AGN 190342, AGN 190342 Tartrate, AGN190342, AGN-190342, AGN190342 (tartrate), AGN190342 tartrate, AGN-190342 Tartrate, Adrenergic Receptor, AdrenergicReceptor, UK14304, UK-14304, UK14304 tartrate, UK-14304 Tartrate, UK 14304, UK 14304 (tartrate), UK 14304 Tartrate, α2A-adrenergic receptor

Compound Identifiers

PubChem CID

54405