Brimonidine Tartrate

SKU: orb1224186

Description

Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.(In Vitro):[3H]Brimonidine (UK 14304) is a full agonist at alpha 2-adrenergic receptors. [3H]Brimonidine (UK 14304) labels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 70359-46-5
• MW: 442.22
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₆BrN₅O₆
• SMILES: C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
• Target: Adrenergic Receptor
• Solubility: Water: 75 mg/mL (169.59 mM); DMSO: 88 mg/mL (198.99 mM)

Bioactivity

• In Vitro:
  [3H]Brimonidine (UK 14304) is a full agonist at alpha 2-adrenergic receptors. [3H]Brimonidine (UK 14304) labels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site [1-3].
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AGN 190342LF | Alphagan P

Quick Database Links

Gene Symbol

Adrenergic Receptor