Brilliant Black BN

SKU: orb1218281

Description

Brilliant black BN (E151) is an azo dye and a food colorant. It is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A.

Key Properties

• CAS Number: 2519-30-4
• MW: 867.68
• Purity: >98% (HPLC)
• Formula: C₂₈H₁₇N₅Na₄O₁₄S₄
• SMILES: [Na+].[Na+].[Na+].[Na+].CC(=O)Nc1ccc(c2cc(c(\N=N\c3ccc(\N=N\c4ccc(cc4)S(=O)(=O)[O-])c5ccc(cc35)S(=O)(=O)[O-])c(O)c12)S(=O)(=O)[O-])S(=O)(=O)[O-]
• Target: Others
• Solubility: DMSO:123 mg/mL (141.75 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Brilliant black BN (E151)(intraperitoneal injection; 200 mg/kg; 14 days)exhibits mild illness with clinical scores less than 3 and subsequently recovered when compared with PBS-group. All E151 270 treated mice are completely protected throughout the experiment. Animal model: 14-days old AG129 mice with EV71. Dosage: 200 mg/kg. Administration: Intraperitoneal injection. Result: Had a Protective eddect on EV71 challenged AG129 mice by dye E151.
• In Vitro:
  Brilliant black BN (E151) inhibits the interaction between EV71 and its cellular uncoating factor cyclophilin A. Brilliant black BN (E151) inhibited the infection EV71 -GFP at a concentration of 300 μM as evidenced from the reduced GFP signals. Brilliant black BN (E151)exhibits the inhibition of EV71 -GFP as a dose-dependent manner in infected RD cells, exhibits an IC50 value of 10.1 μM. Brilliant black BN (E151) is able to inhibit all tested 28 EV71, CVA16 and CVA6 strains. In rhabdomyosarcoma cells, 50% inhibitory concentration 29 of the dye E151 for various strains of EV71 ranged from 2.39 μM to 28.12 μM, whereas its 50% cytotoxic concentration is 1870 μM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E 151

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