Brevianamide F

SKU: orb1304423

Description

Brevianamide F, a natural 2,5-diketopiperazine also known as cyclo(L-Pro-L-Trp), is a research chemical noted for its inhibitory activity against the breast cancer resistance protein (BCRP). It is utilized in vitro to study multidrug resistance mechanisms and probe BCRP function in oncology research.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 38136-70-8
• MW: 283.33
• Purity: 98.82% (May vary between batches)
• Formula: C₁₆H₁₇N₃O₂
• SMILES: O=C1N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N2CCC[C@@H]12
• Target: PI3K,BCRP,Antibacterial
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.06 mM);DMSO:50 mg/mL (176.47 mM)

Bioactivity

• Target IC50:
  PI3Kα:4.8 μM (IC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

breast cancer resistance protein, Brevianamide F, Cyclo(L-Pro-L-Trp), cyclo-(L-Trp-L-Pro), Cyclo-L-tryptophyl-L-proline, antibacterial, Bacterial, inhibit, mycotoxin, Inhibitor, PI3Kα, PI3K, Phosphoinositide 3-kinase

Compound Identifiers

PubChem CID

181567