BRD4 Inhibitor-10

SKU: orb1308525

Description

BRD4 Inhibitor-10 is a potent and selective small molecule targeting the first bromodomain (BD1) of BRD4 with an IC50 of 8 nM. This compound is a valuable chemical probe for epigenetic research, utilized in vitro to study transcriptional regulation in oncology and inflammation, and has been employed in vivo in preclinical cancer models.

Research Area

Epigenetics & Chromatin, Epigenetics & Chromatin; Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1660117-38-3
• MW: 429.51
• Purity: 99.53% (May vary between batches)
• Formula: C₂₅H₂₇N₅O₂
• SMILES: C[C@@H](c1ccccc1)n1c(nc2cnc(cc12)C1CCOCC1)-c1cc(C)c(=O)n(C)n1
• Target: Epigenetic Reader Domain
• Solubility: DMSO:125 mg/mL (291.03 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.31 mM)

Bioactivity

• Target IC50:
  BRD4 BD1:8 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRD4-BD1, BRD4 Inhibitor 10, BRD4 Inhibitor10, BRD-4 Inhibitor-10, BRD4 Inhibitor-10, inhibit, Inhibitor, EpigeneticReaderDomain, Epigenetic Reader Domain

Compound Identifiers

PubChem CID

90647162