Braco-19

SKU: orb1700968

Description

Braco-19 is a small molecule research compound that functions as a dual telomerase/telomere and human adenovirus (HAdV) replication inhibitor. It has demonstrated antiviral activity and reduces lipid accumulation in adipocytes, while also suppressing proliferation and telomerase activity in glioblastoma cell models in vitro.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 351351-75-2
• MW: 593.76
• Purity: 97.01% (May vary between batches)
• Formula: C₃₅H₄₃N₇O₂
• SMILES: O=C(NC=1C=CC2=C(N=C3C=C(C=CC3=C2NC4=CC=C(C=C4)N(C)C)NC(=O)CCN5CCCC5)C1)CCN6CCCC6
• Target: Virus Protease,Antiviral,Telomerase,DNA/RNA Synthesis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.37 mM);DMSO:3.19 mg/mL (5.37 mM)

Bioactivity

• In Vivo:
  BRACO-19 (intraperitoneal injection; 2 mg/kg; 3 weeks; starting 6 days after transplantation of UXF1138LX fragments) inhibits tumor growth significantly and under these conditions, marked single-agent antitumor activity is observed, with some animals in the group showing complete regressions (5 of 12 tumors). BRACO-19 (oral administration or intraperitoneal injection; 2 or 5 mg/kg; 3 weeks) oral dosing regimen are always inactive and the animals have to be sacrificed due to high tumor burden before overall termination of the study, Chronic, i.p. BRACO-19 administration, qdx5 is efficient in inhibiting tumor growth in earlystage xenografts but not advanced-stage xenografts.
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• In Vitro:
  At 1 μM, the growth inhibitory effect of BRACO-19 (1.0-10 μM; 5 days) was null, the IC50 of BRACO-19 in UXF1138L cells was 2.5 μM, the IC100 was 5 μM, and BRACO-19 (1 μM; 24 h) significantly reduced the expression of hTERT in the nucleus. In eGFP-transfected HEK 293 cells, BRACO-19 (0-40 μM; 24 h) reduced the growth of AdV viruses in a dose-dependent manner ; BRACO-19 (0-150 μM; 24 h) reduced the band intensity in a concentration-dependent increase; and BRACO-19 interacted specifically with the HAdV GQ, increasing its stability and blocking the propagation of HAdV .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Braco-19, Braco19, Braco 19, Antiviral, Telomerase

Compound Identifiers

PubChem CID

9808666