Braco-19 trihydrochloride

SKU: orb1703663

Description

Braco-19 trihydrochloride

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 1177798-88-7
• MW: 703.14
• Purity: 98.74% (May vary between batches)
• Formula: C₃₅H₄₆Cl₃N₇O₂
• SMILES: Cl.Cl.Cl.CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
• Target: DNA/RNA Synthesis,Virus Protease,Telomerase
• Solubility: H2O:19.8 mg/mL (28.16 mM)

Bioactivity

• In Vivo:
  In nude mice established UXF1138LX Xenografts, BRACO-19 trihydrochloride (2 mg/kg; i.p.) significantly inhibits tumor growth and shows marked single-agent antitumor activity. some animals in the group shows complete regressions (5 of 12 tumors).
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• In Vitro:
  The IC50 for BRACO-19 trihydrochloride (1.0-10 μM) in UXF1138L cells is 2.5 μM, the IC100 is 5 μM. BRACO-19 trihydrochloride (1 μM) dramatically reduces the expression of nuclear hTERT. BRACO-19 trihydrochloride (0-40 μM) dose-dependently decreases the AdV virus growth in eGFP-transinfected HEK 293 cells. BRACO-19 trihydrochloride (0-150 μM) decreases band intensity in an increasing concentration-dependent manner.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRACO 19, BRACO 19 HCl, BRACO 19 Hydrochloride, BRACO19, BRAC-O19, Braco-19, BRACO19 3HCl, BRACO19 HCl, BRAC-O19 HCl, BRACO19 hydrochloride, BRACO-19 Hydrochloride, Braco-19 Trihydrochloride, Telomerase

Compound Identifiers

PubChem CID

10349800