BQ-123

SKU: orb1300461

Description

BQ-123 is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 7.3 nM. This compound is a valuable research tool for investigating the role of ET-1 signaling in cardiovascular diseases, pulmonary hypertension, and cancer, as demonstrated in various in vitro and in vivo studies. It has been evaluated in Phase 2 clinical trials.

Research Area

Pharmacology & Drug Discovery

Key Properties

• Target: Endothelin Receptor
• CAS Number: 136553-81-6
• MW: 610.7
• Purity: ≥95% (May vary between batches)
• Formula: C₃₁H₄₂N₆O₇
• SMILES: [H][C@@]12CCCN1C(=O)[C@@]([H])(CC(O)=O)NC(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC2=O)C(C)C

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cells, BQ 123, BQ123, BQ-123, blood, artery, EndothelinReceptor, Endothelin Receptor, Endothelin A receptor, Inhibitor, inhibit, muscle, smooth, pulmonary, pressure

Compound Identifiers

PubChem CID

443289