Boc-Val-Cit-PAB-PNP

SKU: orb1307484

Description

Boc-Val-Cit-PAB-PNP is a protease-cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) for targeted cancer therapy research. It enables the controlled release of cytotoxic payloads in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 870487-10-8
• MW: 644.673
• Purity: 98.21% (May vary between batches)
• Formula: C₃₀H₄₀N₆O₁₀
• SMILES: O=C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C1)OC2=CC=C([N+]([O-])=O)C=C2
• Target: ADC Linker,PROTAC Linker
• Solubility: DMSO:10 mM

Bioactivity

• In Vitro:
  ADCs consist of an antibody attached to an ADC cytotoxin through an ADC linker.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADC Linker, ADC Linkers, ADCLinker, Antibody-drug conjugates linkers, Boc Val Cit PAB PNP, BocValCitPABPNP, Boc-Val-Cit-PAB-PNP, Cleavable, inhibit, Inhibitor

Compound Identifiers

PubChem CID

75412383