Boc-Val-Cit-PAB-PNP

SKU: orb1307484

Description

Boc-Val-Cit-PAB-PNP is a protease-cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) for targeted cancer therapy research. It enables the controlled release of cytotoxic payloads in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 870487-10-8
• MW: 644.67
• Purity: 97.90% (May vary between batches)
• Formula: C₃₀H₄₀N₆O₁₀
• SMILES: CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(COC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc1
• Target: PROTAC Linker,ADC Linker
• Solubility: DMSO:10 mM

Bioactivity

• In Vitro:
  ADCs consist of an antibody attached to an ADC cytotoxin through an ADC linker.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADC Linker, ADC Linkers, ADCLinker, Antibody-drug conjugates linkers, Boc Val Cit PAB PNP, BocValCitPABPNP, Boc-Val-Cit-PAB-PNP, Cleavable, inhibit, Inhibitor

Compound Identifiers

PubChem CID

75412383