BMY 7378 dihydrochloride

SKU: orb1304593

Description

BMY 7378 dihydrochloride is a selective α1D-adrenergic receptor antagonist and a weak partial agonist at the 5-HT1A receptor. This compound is utilized in research to investigate adrenergic and serotonergic systems in cardiovascular and neurological studies, both in vitro and in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 21102-95-4
• MW: 458.42
• Purity: 99.08% (May vary between batches)
• Formula: C₂₂H₃₃Cl₂N₃O₃
• SMILES: Cl.COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1.Cl
• Target: Dopamine Receptor,Adrenergic Receptor,5-HT Receptor
• Solubility: DMSO:85 mg/mL (185.42 mM);Ethanol:16 mg/mL (34.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.91 mM);H2O:84 mg/mL (183.24 mM)

Bioactivity

• Target IC50:
  α1B-adrenoceptor (hamster):600 nM (Ki)|5-HT1A:8.3(pIC50)|5-HT1C:6.4(pIC50)|α1A-adrenoceptor (rat):800 nM (Ki)|α2C-adrenoceptor:6.54(pKi)|α1D-adrenoceptor:8.2(pKi)|D2 receptor:7.4(pIC50)
• In Vivo:
  The antagonistic effect produced by WAY 100635 was mediated by increasing the concentration of 5-HT to 300 μM with an IC50 of 0.95 nM. PluriSIn 1 causes central cell death by activating apoptosis.PluriSIn 1 produces ER stress by interacting with hPSCs.PluriSIns 1 (20 μM) has an inhibitory effect on teratoma formation by undifferentiated hPSCs, and it also inhibits the development of mPSCs and mouse embryos.PluriSIns 1 (20 μM) induces a protein-like response to hPSCs by interacting with hPSCs. PluriSIns 1 (20 μM) induced an approximately 30% reduction in protein synthesis by interacting with hPSCs.
• In Vitro:
  The antagonistic effect produced by WAY 100635 was mediated by increasing the concentration of 5-HT to 300 μM with an IC50 of 0.95 nM. PluriSIn 1 causes central cell death by activating apoptosis.PluriSIn 1 produces ER stress by interacting with hPSCs.PluriSIns 1 (20 μM) has an inhibitory effect on teratoma formation by undifferentiated hPSCs, and it also inhibits the development of mPSCs and mouse embryos.PluriSIns 1 (20 μM) induces a protein-like response to hPSCs by interacting with hPSCs. PluriSIns 1 (20 μM) induced an approximately 30% reduction in protein synthesis by interacting with hPSCs.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Adrenergic Receptor, AdrenergicReceptor, alpha 1-adrenoceptor, 5-HT1A, 5-HT1A receptor, 5-HT1C, 5-HT Receptor, 5HT Receptor, 5-hydroxytryptamine Receptor, 5HTReceptor, BMY 7378, BMY 7378 dihydrochloride, BMY 7378 Dihydrochloride, BMY7378, BMY-7378, BMY7378 Dihydrochloride, BMY-7378 Dihydrochloride, BMY7378 HCl, Dopamine Receptor, DopamineReceptor, D2, Beta Receptor, inhibit, Inhibitor, selective, Serotonin Receptor, spontaneously hypertensive rats, α2C-adrenoceptor, α1D-adrenoceptor

Compound Identifiers

PubChem CID

210172