BMS-986242

SKU: orb1298317

Description

BMS-986242

Research Area

Metabolism Research

Key Properties

• CAS Number: 1923844-48-7
• MW: 410.91
• Purity: 98.90% (May vary between batches)
• Formula: C₂₄H₂₄ClFN₂O
• SMILES: [H][C@]1(CC[C@@H](CC1)c1ccnc2ccc(F)cc12)[C@@H](C)NC(=O)c1ccc(Cl)cc1
• Target: IDO,Indoleamine 2,3-Dioxygenase (IDO)
• Solubility: DMSO:250 mg/mL (608.41 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.17 mM)

Bioactivity

• In Vivo:
  BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) demonstrates dose-proportional exposure and significantly reduces tumor kynurenine concentration at all three doses.
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• In Vitro:
  BMS-986242 demonstrates a higher propensity for oxidative metabolism and reduced susceptibility to glucuronidation. It exhibits an IC50 greater than 25 μM for all targets except for nAChR a1 (IC50=12.3 μM) and nAChR a7 (IC50 greater than 6 μM with approximately 20% maximum inhibition).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

active, cancer, BMS986242, BMS-986242, BMS 986242, glucuronidation, Inhibitor, IDO, IDO1, Indoleamine2,3Dioxygenase(IDO), Indoleamine 2,3Dioxygenase (IDO), Indoleamine 2,3-Dioxygenase (IDO), Indoleamine2,3Dioxygenase, Indoleamine 2,3-Dioxygenase, inhibit, orally, potent, selective

Compound Identifiers

PubChem CID

121318866