BMS-986242

SKU: orb1218543

Description

BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.

Key Properties

• CAS Number: 1923844-48-7
• MW: 410.91
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₄ClFN₂O
• SMILES: O=C(N[C@@H]([C@H]1CC[C@@H](C2=CC=NC3=CC=C(F)C=C23)CC1)C)C4=CC=C(Cl)C=C4
• Target: IDO
• Solubility: DMSO:250 mg/mL (608.41 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  BMS-986242 (3~30 mg/kg; p.o. ; 0~24 hours) exhibits dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses. Animal model: nu/nu Mouse. Dosage: 3~30 mg/kg. Administration: p.o. Result: Exhibited dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses.
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• In Vitro:
  BMS-986242 is more prone to oxidative metabolism and less susceptible to glucuronidation. BMS-986242 shows IC50>25 μM for all targets except nAChR a1 (IC50 = 12.3 μM) and nAChR a7 (IC50>6 μM with ~20 % max inhibition).
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS986242 | BMS 986242

Quick Database Links

Gene Symbol

IDO