BMS-794833

SKU: orb1305509

Description

BMS-794833 is an ATP-competitive small molecule inhibitor targeting Met and VEGFR2 kinases. It serves as a prodrug for the active metabolite BMS-817378. This compound is utilized in cancer research for investigating angiogenesis and tumor growth in both cellular and animal models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1174046-72-0
• MW: 468.84
• Purity: 98.00% (May vary between batches)
• Formula: C₂₃H₁₅ClF₂N₄O₃
• SMILES: Nc1nccc(Oc2ccc(NC(=O)c3c[nH]cc(-c4ccc(F)cc4)c3=O)cc2F)c1Cl
• Target: VEGFR,c-Met/HGFR
• Solubility: DMSO:117.5 mg/mL (250.62 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.04 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  VEGFR2:15 nM|MET:1.7 nM
• In Vivo:
  BMS794833 inhibits the activation of the Met receptor in the gastric cancer cell line GTL-16, with an IC50 of 39 nM.
• In Vitro:
  At a dosage of 25 mg/kg, BMS798433 exhibited complete inhibition of tumor growth in the U87 glioblastoma model. In the GTL-16 human gastric tumor xenograft model, treatment with BMS798433 for 14 days resulted in a Tumor Growth Inhibition (TGI) rate of over 50% within at least one tumor doubling time, with no significant toxicity observed during the period.
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• Cell Research:
  GTL-16 cells are seeded into 96 well plates and incubated for 24 hours. BMS798433 is dissolved in DMSO at 10 mM and diluted with culture medium before use. Then BMS798433 is added to the cells for 72 hours. After that, MTS assay is used to measure the IC50.(Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Vascular endothelial growth factor receptor, VEGFR, VEGFR2, inhibit, Met, Inhibitor, HGFR, BMS 794833, BMS794833, BMS-794833, c-Met, cMet, c-Met/HGFR, cMet/HGFR

Compound Identifiers

PubChem CID

44155856