BMS-794833

SKU: orb1226878

Description

BMS794833 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7 nM/15 nM; also inhibits Ron, Axl and Flt-3 with IC50200 RTKs, non-RTKs and serine/threonine kinases; inhibits the cell growth in GTL-16 gastric carcinomas with an IC50 of 39 nM; active in multiple tumor models.Solid Tumors Phase 1 Clinical.

Key Properties

• CAS Number: 1174046-72-0
• MW: 468.84
• Purity: >98% (HPLC)
• Formula: C₂₃H₁₅ClF₂N₄O₃
• SMILES: C1=CC(=CC=C1C2=CNC=C(C2=O)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F)F
• Target: c-Met/HGFR
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  BMS-794833 is active by greater than 50% tumor growth inhibition for at least one tumor doubling time in the GTL-16 gastric carcinoma model. No toxicity is observed at any of the dose levels when administered once daily for a duration of 14 days.
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• In Vitro:
  BMS794833 inhibits Met receptor activated gastric carcinoma cell line, GTL-16, with an IC50 of 39 nM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS794833

Quick Database Links

Gene Symbol

c-Met/HGFR