BMS-1166-N-piperidine-CO-N-piperazine

SKU: orb1984546

Description

BMS-1166-N-piperidine-CO-N-piperazine is a bifunctional molecule incorporating a PD-1/PD-L1 inhibitor linked to a PROTAC moiety. It serves as a key intermediate for synthesizing PROTAC PD-1/PD-L1 degrader-1, a compound which disrupts the PD-1/PD-L1 interaction with an IC50 of 39.2 nM in biochemical assays. This tool compound is designed for research into targeted protein degradation within cancer immunology.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2447066-14-8
• MW: 707.27
• Formula: C₄₁H₄₃ClN₄O₅
• SMILES: Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3CCCCC3C(=O)N3CCNCC3)cc2Cl)cccc1-c1ccc2OCCOc2c1
• Target: Target Protein Ligand-Linker Conjugates,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

154573772