BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride

SKU: orb1819259

Description

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride, a resorcinol di-Ph ether scaffold-based programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitor, inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM. It contains the target protein PD-1/PD-L1 ligand and PROTAC linker, which can be used to synthesize PROTAC PD-1/PD-L1 degrader-1 and has anticancer activity. Additionally, it serves as a diluent for the preparation of tablets for direct compression.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2691796-83-3
• MW: 780.18
• Purity: 98.94%
• Formula: C₄₁H₄₅Cl₃N₄O₅
• SMILES: Cl.Cl.Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3CCCCC3C(=O)N3CCNCC3)cc2Cl)cccc1-c1ccc2OCCOc2c1
• Target: PD-1/PD-L1,Target Protein Ligand-Linker Conjugate

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

BMS-1166-N-piperidine-CO-N-piperazine, BMS1166NpiperidineCONpiperazinedihydrochloride, PD-1, PD1/PDL1, PD1, PD-1/PD-L1, PD-L1, PDL1

Compound Identifiers

PubChem CID

162646773