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Bleximenib

SKU: orb3177773

Description

Bleximenib (JNJ-75276617) oxalate is an orally active and highly selective menin–KMT2A interaction inhibitor, with IC50 values of 0.1 nM in humans, 0.045 nM in mice, and ≤0.066 nM in dogs, Bleximenib effectively suppresses tumor cell proliferation while inducing apoptosis and cellular differentiation. Bleximenib serves as a powerful investigational agent for leukemia and other KMT2A-driven malignancies in preclinical cancer research.

Research Area

Epigenetics & Chromatin

Images & Validation

Key Properties

CAS Number2654081-35-1
MW599.8
Purity98.00% (May vary between batches)
FormulaC32H50FN7O3
SMILES[C@@H](CCCN(CCOC)C)(C(C)C)N1CC2(CN(CC2)C=3C(OC4=C(C(N(C(C)C)CC)=O)C=C(F)C=C4)=NN=CN3)C1
TargetHistone Methyltransferase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Protocol Information

Available Sizes

Select a size below

1 mg
$ 240.00
5 mg
$ 530.00
1 ml x 10 mM (in DMSO)
$ 690.00
10 mg
$ 770.00
25 mg
$ 1,220.00
50 mg
$ 1,720.00
DispatchUsually dispatched within 5-10 working days
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