Blarcamesine hydrochloride

SKU: orb1303150

Description

Blarcamesine hydrochloride (AVex-73 hydrochloride) is a small molecule agonist of the Sigma-1 Receptor with an IC50 of 860 nM. This compound is utilized in research to investigate neuroprotection, neurodegenerative diseases, and neuropathic pain in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 195615-84-0
• MW: 317.85
• Purity: 99.95% (May vary between batches)
• Formula: C₁₉H₂₄ClNO
• SMILES: Cl.CN(C)CC1CCOC1(c1ccccc1)c1ccccc1
• Target: Sigma receptor
• Solubility: DMSO:55 mg/mL (173.04 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.29 mM)

Bioactivity

• Target IC50:
  σ1 receptor:860 nM
• In Vivo:
  The pretreatment of Blarcamesine(1/3 mg/kg) dose-dependently reduces the scopolamine-induced alternation deficit. The pretreatment with Blarcamesine(>0.3 mg/kg) dose-dependently and significantly attenuates the impairments of step-through latency. The Blarcamesine(1mg/kg) dose-dependently blocks the recognition memory deficit. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by Blarcamesine(0.1/1mg/kg). Seven days after injections, Blarcamesineattenuates the decrease in Ser9 phosphorylation induced by the peptide (0.3/1mg/kg).
• Animal Research:
  Drugs (including Anavex 2-73) are solubilized in physiological saline at the concentration of 5 mg/mL.Male mice aged 7-9 weeks and weighing 32±2 g are used. Drugs (including Anavex 2-73) are brought up to each dose by dilution and injected in a volume of 100 μL/20 g body weight. Animals are used between days 1 and 9 after i.c.v. injections for behavioral testing or killed before biochemical measures.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sigmareceptor, Sigma Receptor, Sigma receptor, σ1, Blarcamesine, Blarcamesine hydrochloride, Blarcamesine Hydrochloride, Anavex 2-73, AVex-73 hydrochloride, AVex-73 Hydrochloride, AE37 Hydrochloride, AE-37 Hydrochloride, AE-37 hydrochloride, AE 37 Hydrochloride, Inhibitor, inhibit

Compound Identifiers

PubChem CID

46932299