Anavex 2-73

SKU: orb1223204

Description

Anavex 2-73 is a Sigma-1 Receptor agonist (IC50: 860 nM).(In Vivo):The pre-administration of Blarcamesine leads to a dose-dependent attenuation of the scopolamine induced alternation deficit, significant at 1 and 3 mg/kg. The pre-treatment with Blarcamesine hydrochloride attenuates the impairments of step-through latency, dose dependently and significantly at doses higher than 0.3 mg/kg. The Blarcamesine hydrochloride treatment dose-dependently blocks the recognition memory deficit, with a significant effect measured at 1 mg/kg. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by Blarcamesine hydrochloride at 0.1 and 1 mg/kg dose. Seven days after injections, Blarcamesine hydrochloride attenuates the decrease in Ser9 phosphorylation induced by the peptide at 0.3 and 1 mg/kg. The Blarcamesine hydrochloride treatment dose-dependently prevents the Aβ25-35-induced increase in Aβ1-42 content, with a significant effect at the highest dose tested.

Key Properties

• CAS Number: 195615-84-0
• MW: 317.85
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₄ClNO
• SMILES: CN(C)CC1CCOC1(C2=CC=CC=C2)C3=CC=CC=C3.Cl
• Target: σ1
• Solubility: DMSO : 37.5 mg/mL 117.98 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AE-37 hydrochloride

Quick Database Links

Gene Symbol

σ1