BL-918

SKU: orb1299037

Description

BL-918 is a potent small molecule activator of ULK1 (Unc-51 like autophagy activating kinase 1), exhibiting an EC50 of 24.14 nM. It serves as a valuable research tool for investigating autophagy signaling pathways in both cellular and animal models of cancer and neurodegenerative diseases.

Research Area

Cell Biology

Key Properties

• CAS Number: 2101517-69-3
• MW: 533.44
• Purity: >99.99% (May vary between batches)
• Formula: C₂₃H₁₅F₈N₃OS
• SMILES: Fc1ccc(NC(=O)[C@H](NC(=S)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c2ccccc2)c(F)c1
• Target: Autophagy
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (3.75 mM);DMSO:27.5 mg/mL (51.55 mM)

Bioactivity

• Target IC50:
  ULK1:0.719 μM (Kd)|ULK1:24.14 nM(EC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BL 918, BL918, BL-918, Autophagy, autophagic, cytoprotective, disease, Inhibitor, kinase, inhibit, Orally, Parkinson's, Unc-51 like kinase, ULK1, ULK

Compound Identifiers

PubChem CID

146014432