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BIX02189 (b)

SKU: orb1226998

Description

BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

Images & Validation

Key Properties

CAS Number1094614-85-3
MW440.54
Purity>98% (HPLC)
FormulaC27H28N4O2
SMILESCN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4
TargetERK
SolubilityEthanol: 80 mg/mL (181.59 mM); DMSO: 60 mg/mL warmed (136.19 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • (E/Z)-BIX 02189 [orb1305514]

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    1094614-85-3

    440.54

    C27H28N4O2

    5 mg, 10 mg, 25 mg, 50 mg, 200 mg, 1 mg, 100 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

BIX02189 (b) (orb1226998)

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

2 mg
$ 90.00
5 mg
$ 130.00
10 mg
$ 190.00
25 mg
$ 330.00
50 mg
$ 540.00
100 mg
$ 900.00
200 mg
$ 1,250.00
500 mg
$ 1,800.00