(E/Z)-BIX 02189

SKU: orb1305514

Description

(E/Z)-BIX 02189 is a stereoisomer of the MEK5 inhibitor BIX 02189. This chemical probe is utilized in biochemical studies to investigate the ERK5 signaling pathway in both cellular and enzymatic assays.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1094614-85-3
• MW: 440.54
• Purity: 99.89% (May vary between batches)
• Formula: C₂₇H₂₈N₄O₂
• SMILES: C(NC1=CC(CN(C)C)=CC=C1)(=C2C=3C(NC2=O)=CC(C(N(C)C)=O)=CC3)C4=CC=CC=C4
• Target: TGF-beta/Smad,MEK,ERK
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:74 mg/mL (167.98 mM);DMSO:22.73 mg/mL (51.6 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.54 mM)

Bioactivity

• Target IC50:
  MEK5:1.5 nM|TGFβRI:580 nM|MAPK14 (p38 alpha):3.7 μM|JAK3:440 nM|RPS6KA3/RSK2:2.1 μM|RPS6KA6/RSK4:990 nM|ERK5:59 nM|CSF1R (FMS):46 nM|c-Kit:1.1 μM|FGFR1:1 μM|LCK:250 nM|SRC:7.6 μM|Abl-1:2.4 μM
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BIX 02189, BIX02189, BIX-02189, MEK1, MEK2, MEK5, ERK5, TGFbeta/Smad, TGF-beta, TGFb, TGF-b/Smad, TGFbeta, Smad, TGFβR1, TGFβ, TGF-β/Smad

Compound Identifiers

PubChem CID

135659062