Bikinin

SKU: orb1306951

Description

Bikinin (Abrasin) is a potent and selective inhibitor of plant GSK-3/Shaggy-like kinases. It functions by activating brassinosteroid (BR) signaling pathways downstream of the receptor, making it a valuable chemical probe for studying BR-mediated plant growth and development in both in vitro and in vivo experimental systems.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 188011-69-0
• MW: 273.08
• Purity: 99.86%
• Formula: C₉H₉BrN₂O₃
• SMILES: OC(=O)CCC(=O)NC1=NC=C(Br)C=C1
• Target: GSK-3
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.32 mM);DMSO:45 mg/mL (164.79 mM)

Bioactivity

• In Vivo:
  Bikinin directly inhibited BIN2 in Arabidopsis GSK-3s and activated oleuropein steroid-dependent gene expression.Bikinin also inhibited RD26 expression and, in the case of RD26pro:GUS, NaCl (150 mM)-induced GUS activity.
• In Vitro:
  Bikinin directly inhibited BIN2 in Arabidopsis GSK-3s and activated oleuropein steroid-dependent gene expression.Bikinin also inhibited RD26 expression and, in the case of RD26pro:GUS, NaCl (150 mM)-induced GUS activity.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bikinin, Abrasin, inhibit, GSK3, GSK-3, Glycogen synthase kinase 3, Glycogen synthase kinase-3, Inhibitor, Shaggy-like kinase

Compound Identifiers

PubChem CID

647833